The Department of Experimental Medicine was founded in July 2010 following the reorganization of the Departments of Sapienza, and includes part of the staff belonging to the old Department of "Experimental Medicine and Pathology" and the staff of the former Department of "Medical Physiopathology". Currently the Department brings together 81 professors from the Faculty of Medicine and Dentistry (17 PO, 27 PA and 37 Researchers), divided into the two sections of General Pathology and Clinical Pathology and of Medical Physiopathology, Food Science and Endocrinology, with the aim of promoting translational and multidisciplinary research activities. The research activity focuses on some particularly relevant areas among the groups belonging to the Department, such as molecular oncology, viral oncology, oncoimmunology, regenerative medicine, molecular genetics, clinical and molecular endocrinology, clinical and molecular biology of diabetes and of diseases of bone and water-salt metabolism, clinical and molecular biology in neuroendocrinology and cardiovascular endocrinology, clinical and molecular andrology, reproductive biology and biotechnology, nutritional science and clinical and molecular aspects of the adipose organ, epigenomics, the study of inflammatory and autoimmune diseases and infections and immunity, neurophysiology, platelet physiopathology and psychoneuroimmunology.

The care activity (diagnostic and clinical) is carried out in two day hospitals (a - andrological endocrinology and internal medicine; b - obesity, eating disorders and metabolic diseases) and in the clinics and laboratories of andrology, endocrinological diagnosis and diabetology, endocrinology and thyroid diseases, medical genetics, cellular therapies, regenerative medicine, immunology and immunopathology, cellular pathology, genetic-metabolic diseases, clinical and transplant pathology.

The teaching activity is diversified and carried out in the Degree Courses in Medicine and Surgery, in the Degree Courses for Health Professions, in various post-graduate training courses, two Specialization Schools in Endocrinology and Metabolic Diseases and Nutrition Science and in Research Doctorate Courses and I and II level Masters.